Multidrug resistance (MDR) is a major impediment to curative cancer chemotherapy.The ATP-Binding Cassette transporters ABCG2, ABCB1 and ABCC2 form a unique defense network against multiple structurally and functionally distinct chemotherapeutics, thereby resulting in MDR.Thus, deciphering novel mechanisms of MDR and their overcoming is a major goal
Abstract Duchenne muscular dystrophy (DMD) is an X-linked disease caused by mutations in the DMD gene and loss of the protein dystrophin.The absence of dystrophin leads to myofiber membrane fragility and necrosis, with eventual muscle atrophy and contractures.Affected boys typically die in their second or third decade due to either respiratory fail
Exhaustive formal verification for systems of systems (SoS) is impractical and cannot be applied on a large scale.In this paper we propose to use statistical model checking for efficient verification of SoS.We address three relevant aspects for systems of systems: 1) the model of the SoS, which includes stochastic aspects; 2) the formalization of t
Forest fire is one of the most serious environmental problems in Kenya that influences human activities, climate change and biodiversity.The main goal of this study is to apply medium resolution sensors (Landsat 8 OLI and Sentinel 2 MSI) to produce burnt area severity maps that will include small fires (< 100 ha) in order to spider
Accurate and rapid detection of potato surface defects is crucial for advancing intelligent potato sorting.To elevate detection accuracy as well as shorten the computational load of the model, this paper proposes a lightweight Flaw-YOLOv5s algorithm for potato surface defect detection.Firstly, Depthwise Separable Convolution (DWConv) is used to dis